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Doctor's Best, SAM-e (S-Adenosyl Methionine), Double Strength, 400 mg, 60 Enteric Coated Tablets

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Doctor's Best, SAM-e (S-Adenosyl Methionine), Double Strength, 400 mg, 60 Enteric Coated Tablets

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Doctor's Best, SAM-e (S-Adenosyl Methionine), Double Strength, 400 mg, 60 Enteric Coated Tablets

In Stock
400 mg
400 mg
200 mg
60 Tablets
30 Tablets
60 Tablets
  • Expiration Date: 01/2020
  • Shipping Weight:
    0.3 lbs
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  • Product Code: DRB-00252
  • UPC Code: 753950002524
  • Package Quantity: 60 Tablets
  • Dimensions:
    6.3 x 3.3 x 2 in, 0.25 lbs
    Switch to Metric units
Frequently Purchased Together
Product Overview


  • Science-Based Nutrition
  • Helps Enhanced Mood and Neural Function
  • Helps Promote Joint Comfort and Mobility
  • Helps Support Liver Health and Detoxification
  • Vegan
  • Dietary Supplement
  • Gluten Free / Soy Free / Vegan

Our Double Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e available providing slow and targeted release for improved GI tolerance and absorption. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.

SAM-e (S-Adenosyl Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody. Doctor's Best SAM-e helps replenish your SAM-e levels and promote a healthy mood.

Supplementing with SAM-e

Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate bio-chemical activity in the human body.

SAM-e and Mood and Cognitive Function

SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body's antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.

SAM-e and Joint Function

In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.

SAM-e and Liver Function

SAM-e helps support healthy levels of glutathione, a critical anti-oxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Double Strength SAM-e is sealed in blister packs for freshness and stability.

Suggested Use

Adult Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Other Ingredients

Microcrystalline cellulose, magnesium hydroxide, stearic acid, calcium chloride anhydrous, magnesium stearate, colloidal silica anhydrous, calcium oxide, magnesium silicate, natural food glaze, arginine base, glycerol, sodium alginate.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Store product in a cool, dry place.

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 servings
  Amount per serving % Daily Value
S-Adenosyl Methionine (from 800 mg SAM-e tosylate disulfate) 400 mg
† Daily Value not established.
iHerb Customer Reviews

It works great actually.

Posted by iHerb Customer on Feb 16, 2018 | Verified Purchase

It gave me more energy. I can feel increasing energy levels.

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Mixed Bag

Posted by iHerb Customer on Feb 08, 2018 | Verified Purchase

Got them for my wife, she so far has noticed very little effect after taking for a month but I would suggest trying them, it could be an individual thing.

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great product

Posted by iHerb Customer on Feb 07, 2018 | Verified Purchase

i cant believe the difference this supplement has made to my energy level. works best with b vitamins. will highly recommend

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Changed Formula Now Causes Diarrhea

Posted by iHerb Customer on Jan 22, 2018 | Verified Purchase

I have used SAM-e from Doctor's Best for 8 years. The batch I received this past fall (two boxes, one of which I gave to my boyfriend) caused Diarrhea. I realize that this was a listed side effect of SAM-e, but I have never experienced this until now. The enteric coating seems to be a bit different as well. Really disappointed. I am writing this because I have made my second attempt at taking this - hoping the first time was a fluke - but am sick again. And to be clear, my bf and I were in separate countries with 2 weeks away from each other by the time this started making us both sick in November.

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Excellent as a Mood Stabiliser

Posted by iHerb Customer on Dec 31, 2017 | Verified Purchase

The best recommendation I can give this product is that when I ran out and forgot to order more, my mood and ability to keep positive thoughts declined rapidly over a few weeks. I have suffered depression in the past and didn't want to go down that spiral again so after trying to work out what I was doing differently and realising I hadn't been taking these tablets, I was able to go back on them and rectify the situation quickly. I also have intermittent problems with my liver so find this assists in normal detoxification. Otherwise any additional loads on my body (like too much fried foods, chemical smells, alcohol) and not able to be coped with which increases physical symptoms like pain, sluggishness and fatigue. I have used this product for a while now and love it.

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